Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma

Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma

Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) modulates various cell functions through IGF-dependent or independent mechanisms. However, its biological roles in the radiosensitivity of oral squamous cell carcinoma (OSCC) remain largely unknown. The purpose of this study was to determi...

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Bibliographic Details
Main Authors: Junki Sakata, Akiyuki Hirosue, Ryoji Yoshida, Yuichiro Matsuoka, Kenta Kawahara, Hidetaka Arita, Hikaru Nakashima, Tatsuro Yamamoto, Masashi Nagata, Sho Kawaguchi, Shunsuke Gohara, Yuka Nagao, Keisuke Yamana, Ryo Toya, Ryuji Murakami, Yoshikazu Kuwahara, Manabu Fukumoto, Hideki Nakayama
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
dna repair
igfbp-3
oral squamous cell carcinoma
dna-pkcs
radiosensitivity
Online Access:https://www.mdpi.com/2072-6694/12/2/494

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https://www.mdpi.com/2072-6694/12/2/494

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