PACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: Involvement of the mitochondrial apoptotic pathway

PACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: Involvement of the mitochondrial apoptotic pathway

Cisplatin is a chemotherapeutic agent whose use is limited by side effects including neuropathies. In proliferating cells, toxic action of cisplatin is based on DNA interactions, while, in quiescent cells, it can induce apoptosis by interacting with proteins. In the present study, we compared cytoto...

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Bibliographic Details
Main Authors: Nicolas Aubert, David Vaudry, Anthony Falluel-Morel, Arnaud Desfeux, Cécile Fisch, Philippe Ancian, Stéphane de Jouffrey, Jean-François Le Bigot, Alain Couvineau, Marc Laburthe, Alain Fournier, Vincent Laudenbach, Hubert Vaudry, Bruno J. Gonzalez
Format: Article
Language:English
Published: Elsevier 2008-10-01
Series:Neurobiology of Disease
Subjects:
Neuroprotection
Chemotherapy
Apoptosis
Cerebellum
Bax
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001320

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http://www.sciencedirect.com/science/article/pii/S0969996108001320

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