Preparation and Release Profiles in Vitro/Vivo of Galantamine Pamoate Loaded Poly (Lactideco-Glycolide) (PLGA) Microspheres

Preparation and Release Profiles in Vitro/Vivo of Galantamine Pamoate Loaded Poly (Lactideco-Glycolide) (PLGA) Microspheres

Patient’s poor compliance and the high risk of toxic effects limit the clinical use of galantamine hydrobromide. To overcome these drawbacks, the sustained-release galantamine pamoate microspheres (GLT-PM-MS) were successfully developed using an oil/water emulsion solvent evaporation method in this...

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Bibliographic Details
Main Authors: Liping Du, Shankui Liu, Guizhou Hao, Li Zhang, Miaomiao Zhou, Yueqing Bao, Bing Ding, Qinyong Sun, Guimin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
galantamine
microspheres
physicochemical characterization
in vitro release
in vivo pharmacokinetic behavior
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.619327/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.619327/full

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