Mechanistic Insights into the Inhibition of SARS-CoV-2 Main Protease by Clovamide and Its Derivatives: In Silico Studies

Mechanistic Insights into the Inhibition of SARS-CoV-2 Main Protease by Clovamide and Its Derivatives: In Silico Studies

The novel coronavirus SARS-CoV-2 Main Protease (M<sup>pro</sup>) is an internally encoded enzyme that hydrolyzes the translated polyproteins at designated sites. The protease directly mediates viral replication processes; hence, a promising target for drug design. Plant-based natural pro...

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Bibliographic Details
Main Authors: Naike Ye, Francesco Caruso, Miriam Rossi
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biophysica
Subjects:
SARS-CoV-2
main protease
clovamide
covalent inhibition
protease inhibitor
inhibition mechanism
Online Access:https://www.mdpi.com/2673-4125/1/4/28

Internet

https://www.mdpi.com/2673-4125/1/4/28

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