EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo

Despite a well-established role for the epidermal growth factor receptor (EGFR) in tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We labeled endogenous EGFR with GFP by genome-editing of human oral squamous cell carcinoma cells, which were used to examine EGF...

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Bibliographic Details
Main Authors: Itziar Pinilla-Macua, Alexandre Grassart, Umamaheswar Duvvuri, Simon C Watkins, Alexander Sorkin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/31993