Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung injury

Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT/GSK3β pathway via c-MET in radiation-induced lung injury

Abstract Background Radiation-induced lung fibrosis (RILF) is a common complication of thoracic radiotherapy. Alveolar epithelial cells play a crucial role in lung fibrosis via epithelial-mesenchymal transition (EMT). Exosomes derived from mesenchymal stem cells own the beneficial properties to repa...

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Bibliographic Details
Main Authors: Yi Li, Zhufu Shen, Xiao Jiang, Yuanyuan Wang, Zuozhang Yang, Yuchi Mao, Zhixian Wu, Gaofeng Li, Hong Chen
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Radiation-induced lung fibrosis
Epithelial-mesenchymal transition
Exosome
Mesenchymal stem cells
miR-466f-3p
Online Access:https://doi.org/10.1186/s13046-022-02351-z

Internet

https://doi.org/10.1186/s13046-022-02351-z

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