Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line

Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line

Abstract Background The epidermal growth factor receptor (EGFR) is a major regulator of proliferation in tumor cells. Elevated expression levels of EGFR are associated with prognosis and clinical outcomes of patients in a variety of tumor types. There are at least four splice variants of the mRNA en...

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Bibliographic Details
Main Authors: Claus Weinholdt, Henri Wichmann, Johanna Kotrba, David H. Ardell, Matthias Kappler, Alexander W. Eckert, Dirk Vordermark, Ivo Grosse
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Bioinformatics
Subjects:
EGFR
Splice variants
RNAi
Bayesian Information Criterion
Bayesian Gene Selection Criterion
Online Access:http://link.springer.com/article/10.1186/s12859-019-2944-9

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http://link.springer.com/article/10.1186/s12859-019-2944-9

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