Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice

Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice

Perturbed neuronal Ca2+ homeostasis is implicated in Alzheimer's disease, which has primarily been demonstrated in mice with amyloid-β deposits but to a lesser and more variable extent in tauopathy models.In this study, we injected AAV to express Ca2+ indicator in layer II/III motor cortex neur...

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Bibliographic Details
Main Authors: Qian Wu, Yang Bai, Wei Li, Erin E. Congdon, Wenke Liu, Yan Lin, Changyi Ji, Wen-Biao Gan, Einar M. Sigurdsson
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Frontotemporal dementia
Tau
Antibody
Ca2+
Two-photon imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030440X

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http://www.sciencedirect.com/science/article/pii/S096999612030440X

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