Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice
Perturbed neuronal Ca2+ homeostasis is implicated in Alzheimer's disease, which has primarily been demonstrated in mice with amyloid-β deposits but to a lesser and more variable extent in tauopathy models.In this study, we injected AAV to express Ca2+ indicator in layer II/III motor cortex neur...
Main Authors: | Qian Wu, Yang Bai, Wei Li, Erin E. Congdon, Wenke Liu, Yan Lin, Changyi Ji, Wen-Biao Gan, Einar M. Sigurdsson |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999612030440X |
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