A celastrol-based nanodrug with reduced hepatotoxicity for primary and metastatic cancer treatmentResearch in context

A celastrol-based nanodrug with reduced hepatotoxicity for primary and metastatic cancer treatmentResearch in context

Summary: Background: Cancer is the world's leading cause of death and a key hindrance to extending life expectancy. Celastrol, a bioactive compound derived from Tripterygium wilfordii, has been shown to have excellent antitumor activity, but its poor solubility and severe organ toxicity side e...

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Bibliographic Details
Main Authors: Min Zhou, Jiaxing Liao, Wenjing Lai, Rufu Xu, Wuyi Liu, Dandan Xie, Fengling Wang, Zhe Zhang, Jingbin Huang, Rong Zhang, Guobing Li
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:EBioMedicine
Subjects:
Celastrol
Nanodrugs
Hepatotoxicity
Targeted treatment
Primary and metastatic cancer treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642300289X

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http://www.sciencedirect.com/science/article/pii/S235239642300289X

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