Ventrolateral ventromedial hypothalamic nucleus GABA neuron adaptation to recurring Hypoglycemia correlates with up-regulated 5′-AMP-activated protein kinase activity

Ventrolateral ventromedial hypothalamic nucleus GABA neuron adaptation to recurring Hypoglycemia correlates with up-regulated 5′-AMP-activated protein kinase activity

Gamma-aminobutyric acid (GABA) acts on ventromedial hypothalamic targets to suppress counter-regulatory hormone release, thereby lowering blood glucose. Maladaptive up-regulation of GABA signaling is implicated in impaired counter-regulatory outflow during recurring insulin-induced hypoglycemia (RII...

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Bibliographic Details
Main Authors: Abdulrahman Alhamyani, Prabhat R Napit, Haider Ali, Mostafa MH Ibrahim, Karen P Briski
Format: Article
Language:English
Published: AIMS Press 2021-09-01
Series:AIMS Neuroscience
Subjects:
recurrent insulin-induced hypoglycemia
ventrolateral ventromedial hypothalamic nucleus-ventrolateral part
glutamate decarboxylase
ampk
adrenergic receptor
Online Access:https://www.aimspress.com/article/doi/10.3934/Neuroscience.2021027?viewType=HTML

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https://www.aimspress.com/article/doi/10.3934/Neuroscience.2021027?viewType=HTML

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