GABAB receptor regulates proliferation in the high-grade chondrosarcoma cell line OUMS-27 via apoptotic pathways

GABAB receptor regulates proliferation in the high-grade chondrosarcoma cell line OUMS-27 via apoptotic pathways

Abstract Background High-grade chondrosarcoma, which has a high incidence of local recurrence and pulmonary metastasis despite surgical resection, is associated with poor prognosis. Therefore, new and effective adjuvant therapies are urgently required for this disease. Gamma-aminobutyric acid (GABA)...

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Bibliographic Details
Main Authors: Kiyoto Kanbara, Yoshinori Otsuki, Masahito Watanabe, Syunichi Yokoe, Yoshiaki Mori, Michio Asahi, Masashi Neo
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Cancer
Subjects:
Chondrosarcoma
GABAB receptor
Akt signaling
Whole cell patch clamp
Ca2+ channel
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12885-018-4149-4

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http://link.springer.com/article/10.1186/s12885-018-4149-4

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