Blockade of Nuclear β‐Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis

Blockade of Nuclear β‐Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis

Abstract Colorectal cancer (CRC) is one of the most common malignant tumors in the world, with high prevalence and low 5‐year survival. Most of the CRC patients show excessive activation of the Wnt/β‐catenin pathway which is a vital target for CRC treatment. Based on multiple CRC cell lines with dif...

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Bibliographic Details
Main Authors: Can‐Can Zheng, Long Liao, Ya‐Ping Liu, Yan‐Ming Yang, Yan He, Guo‐Geng Zhang, Shu‐Jun Li, Ting Liu, Wen Wen Xu, Bin Li
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Advanced Science
Subjects:
β‐catenin
cell senescence
colorectal cancer
Ran‐binding protein 3
small molecule compounds
Online Access:https://doi.org/10.1002/advs.202202528

Internet

https://doi.org/10.1002/advs.202202528

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