Adolescent Binge Alcohol Enhances Early Alzheimer’s Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation

Adolescent Binge Alcohol Enhances Early Alzheimer’s Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation

Epidemiological studies suggest that heavy alcohol use early in life is associated with increased risk for Alzheimer’s disease (AD). However, mechanisms connecting AD with alcohol use have not been identified. Both heavy alcohol use and AD feature increased proinflammatory signaling. Therefore, we h...

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Bibliographic Details
Main Authors: Alexandra Barnett, Emeraghi David, Aaron Rohlman, Viktoriya D. Nikolova, Sheryl S. Moy, Ryan P. Vetreno, Leon G. Coleman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
neuroinflammation
Alzheiemer’s disease
adolescence
alcohol
amyloid
addiction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.884170/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.884170/full

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