Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation

Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation

Intestinal stem cells are responsible for replenishing cells within the high-turnover intestinal epithelium. Here they show that ribosome dynamics affect intestinal stem cell identity through a mechanism that is triggered by changes in nutrient availability.

Bibliographic Details
Main Authors: Joana Silva, Ferhat Alkan, Sofia Ramalho, Goda Snieckute, Stefan Prekovic, Ana Krotenberg Garcia, Santiago Hernández-Pérez, Rob van der Kammen, Danielle Barnum, Liesbeth Hoekman, Maarten Altelaar, Wilbert Zwart, Saskia Jacoba Elisabeth Suijkerbuijk, Simon Bekker-Jensen, William James Faller
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32220-4

Internet

https://doi.org/10.1038/s41467-022-32220-4

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