Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms

Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms

As one of the main active ingredients from Radix Astragali (RA), orally dosed astragaloside IV (AST) is easily transformed to sapogenin-cycloastragenol (CAG) by deglycosylation in the gastrointestinal tract. Because the potential adverse effects of AST and CAG remain unclear, the present study in th...

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Bibliographic Details
Main Authors: Ruixue Ran, Chunze Zhang, Rongshan Li, Bowei Chen, Weihua Zhang, Zhenying Zhao, Zhiwei Fu, Zuo Du, Xiaolang Du, Xiaolong Yang, Zhongze Fang
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
astragaloside IV
cycloastragenol
UDP-glucuronosyltransferases (UGTs)
herb–drug interactions
Online Access:http://www.mdpi.com/1420-3049/21/12/1616

Internet

http://www.mdpi.com/1420-3049/21/12/1616

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