In silico identification and characterization of the SNPs in the human ASTL gene and their probable role in female infertility

In silico identification and characterization of the SNPs in the human ASTL gene and their probable role in female infertility

Ovastacin (ASTL), a zinc metalloprotease, is released from a fertilized egg during exocytosis of cortical granules which occurs minutes after the sperm and egg fuse. ASTL cleaves ZP2, one of the four primary glycoproteins of human zona pellucida, and this cleavage prevents polyspermy, causes zona pe...

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Bibliographic Details
Main Authors: Kapali Suri, Neha Rajput, Priya Sharma, Aishwarya D. Omble, Kiran Kulkarni, Gagandeep K. Gahlay
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ovastacin
ASTL
fertilization
single nucleotide polymorphism
omics
female infertility
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1151672/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1151672/full

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