Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens.

Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens.

We characterized prime-boost vaccine regimens using heterologous and homologous vector and gene inserts. Heterologous regimens offer a promising approach that focuses the cell-mediated immune response on the insert and away from vector-dominated responses. Ad35-GRIN/ENV (Ad35-GE) vaccine is comprise...

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Bibliographic Details
Main Authors: Silvia Ratto-Kim, Jeffrey R Currier, Josephine H Cox, Jean-Louis Excler, Anais Valencia-Micolta, Doris Thelian, Vicky Lo, Eddy Sayeed, Victoria R Polonis, Patricia L Earl, Bernard Moss, Merlin L Robb, Nelson L Michael, Jerome H Kim, Mary A Marovich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458867?pdf=render

Internet

http://europepmc.org/articles/PMC3458867?pdf=render

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