Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Summary: Spinal long-term potentiation (LTP) at C-fiber synapses is hypothesized to underlie chronic pain. However, a causal link between spinal LTP and chronic pain is still lacking. Here, we report that high-frequency stimulation (HFS; 100 Hz, 10 V) of the mouse sciatic nerve reliably induces spin...

Full description

Bibliographic Details
Main Authors: Li-Jun Zhou, Jiyun Peng, Ya-Nan Xu, Wei-Jie Zeng, Jun Zhang, Xiao Wei, Chun-Lin Mai, Zhen-Jia Lin, Yong Liu, Madhuvika Murugan, Ukpong B. Eyo, Anthony D. Umpierre, Wen-Jun Xin, Tao Chen, Mingtao Li, Hui Wang, Jason R. Richardson, Zhi Tan, Xian-Guo Liu, Long-Jun Wu
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719307260

Internet

http://www.sciencedirect.com/science/article/pii/S2211124719307260

Similar Items