Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.

Glomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans. Mutations or deletions involving alpha3(IV), alpha4(IV), or alpha5(IV) chains of type IV coll...

Full description

Bibliographic Details
Main Authors: Michael Zeisberg, Mona Khurana, Velidi H Rao, Dominic Cosgrove, Jean-Philippe Rougier, Michelle C Werner, Charles F Shield, Zena Werb, Raghu Kalluri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-04-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC1391977?pdf=render

Internet

http://europepmc.org/articles/PMC1391977?pdf=render

Similar Items