Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cells.

Despite the distinctive structure of mitotic chromosomes, it has not been possible to visualise individual chromosomes in living interphase cells, where chromosomes spend over 90% of their time. Studies of interphase chromosome structure and dynamics use fluorescence in-situ hybridisation (FISH) on...

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Bibliographic Details
Main Authors: Iris Müller, Shelagh Boyle, Robert H Singer, Wendy A Bickmore, Jonathan R Chubb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2903487?pdf=render