A Brief Overview of Adaptive Designs for Phase I Cancer Trials

A Brief Overview of Adaptive Designs for Phase I Cancer Trials

Phase I studies are used to estimate the dose-toxicity profile of the drugs and to select appropriate doses for successive studies. However, literature on statistical methods used for phase I studies are extensive. The objective of this review is to provide a concise summary of existing and emerging...

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Bibliographic Details
Main Authors: Anshul Saxena, Muni Rubens, Venkataraghavan Ramamoorthy, Zhenwei Zhang, Md Ashfaq Ahmed, Peter McGranaghan, Sankalp Das, Emir Veledar
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
phase I trial
cancer clinical trial
adaptive design
maximum tolerated dose
dose-limiting toxicity
nonparametric designs
Online Access:https://www.mdpi.com/2072-6694/14/6/1566

Internet

https://www.mdpi.com/2072-6694/14/6/1566

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