Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8<sup>+</sup> T Cells

Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8<sup>+</sup> T Cells

During acute infections, CD8<sup>+</sup> T cells form various memory subpopulations to provide long-lasting protection against reinfection. T central memory (TCM), T effector memory (TEM), and long-lived effector (LLE) cells are circulating memory populations with distinct plasticity, mi...

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Bibliographic Details
Main Authors: Yao Chen, Jian Shen, Moujtaba Y. Kasmani, Paytsar Topchyan, Weiguo Cui
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
CD8 tissue-resident memory T cell
LCMV infection
single-cell RNA-sequencing
heterogeneity
transcriptional regulation
transcription factors
Online Access:https://www.mdpi.com/2073-4409/10/8/2143

Internet

https://www.mdpi.com/2073-4409/10/8/2143

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