Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release

Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release

The evolutionarily conserved Hedgehog (Hh) signaling pathway is crucial for programmed cell differentiation and proliferation. Dispatched (Disp) is a 12-transmembrane protein that plays a critical role in the Hedgehog (Hh) signaling pathway by releasing the dually lipidated ligand HhN from the membr...

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Bibliographic Details
Main Authors: Yitian Luo, Guoyue Wan, Xuan Zhou, Qiuwen Wang, Yunbin Zhang, Juan Bao, Yao Cong, Yun Zhao, Dianfan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
cryo-EM
hedgehog release
hedgehog signaling
membrane protein
three-dimensional structure
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.701826/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.701826/full

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