IL-20 Activates ERK1/2 and Suppresses Splicing of X-Box Protein-1 in Intestinal Epithelial Cells but Does Not Improve Pathology in Acute or Chronic Models of Colitis

IL-20 Activates ERK1/2 and Suppresses Splicing of X-Box Protein-1 in Intestinal Epithelial Cells but Does Not Improve Pathology in Acute or Chronic Models of Colitis

The cytokine Interleukin (IL)-20 belongs to the IL-10 superfamily. IL-20 levels are reported to increase in the intestines of Ulcerative Colitis (UC) patients, however not much is known about its effects on intestinal epithelial cells. Here, we investigated the influence of IL-20 on intestinal epith...

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Bibliographic Details
Main Authors: Md. Moniruzzaman, Kuan Yau Wong, Ran Wang, Hamish Symon, Alexandra Mueller, M. Arifur Rahman, Sumaira Z. Hasnain
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
IL-20
epithelial cells
colitis
goblet cells
ERK1/2
endoplasmic reticulum stress
Online Access:https://www.mdpi.com/1422-0067/24/1/174

Internet

https://www.mdpi.com/1422-0067/24/1/174

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