Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction

Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction

Abstract Background Postinfarction cardiac remodeling presents a compensatory mechanism aimed at mitigating congestive heart failure. It is distinguished by progressive dilatation and hypertrophy of the ventricular chambers, fibrotic alterations, and prolonged apoptosis of cardiomyocytes. The primar...

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Bibliographic Details
Main Authors: Ji Jia, Xing-an Zhao, Si-ming Tao, Jun-wen Wang, Rong-liang Zhang, Hua-lei Dai, Xin-jin Zhang, Ming-hua Han, Bei Yang, Yu Li, Jin-tao Li
Format: Article
Language:English
Published: BMC 2023-12-01
Series:European Journal of Medical Research
Subjects:
Icariin
Myocardial infarction
Ventricular remodeling
Myocardial fibrosis
TGF-β1/Smad signaling pathway
Online Access:https://doi.org/10.1186/s40001-023-01588-4

Internet

https://doi.org/10.1186/s40001-023-01588-4

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