Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide, and liver cancer has increased in mortality due to liver cancer because it was detected at an advanced stages in patients with liver dysfunction, making HCC a lethal cancer. Accordingly, we aim...

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Bibliographic Details
Main Authors: Sanghwa Kim, Minji Lee, Yeonhwa Song, Su-Yeon Lee, Inhee Choi, I-Seul Park, Jiho Kim, Jin-sun Kim, Kang mo Kim, Haeng Ran Seo
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma (HCC)
Argininosuccinate synthase 1(ASS1)
Endoplasmic reticulum (ER) stress
Spheroids
C/EBP homologous protein (CHOP)
Online Access:https://doi.org/10.1186/s13046-021-01912-y

Internet

https://doi.org/10.1186/s13046-021-01912-y

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