TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response

TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response

Summary: Intestinal epithelial tight junction disruption is a primary contributing factor in alcohol-associated endotoxemia, systemic inflammation, and multiple organ damage. Ethanol and acetaldehyde disrupt tight junctions by elevating intracellular Ca2+. Here we identify TRPV6, a Ca2+-permeable ch...

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Bibliographic Details
Main Authors: Avtar S. Meena, Pradeep K. Shukla, Briar Bell, Francesco Giorgianni, Rebeca Caires, Carlos Fernández-Peña, Sarka Beranova, Eitaro Aihara, Marshall H. Montrose, Mehdi Chaib, Liza Makowski, Indira Neeli, Marko Z. Radic, Valeria Vásquez, Jonathan H. Jaggar, Julio F. Cordero-Morales, RadhaKrishna Rao
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722007197

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http://www.sciencedirect.com/science/article/pii/S2211124722007197

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