Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function

Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function

Long-chain acyl-CoA synthetase 1 (ACSL1) contributes more than 90% of total cardiac ACSL activity, but its role in phospholipid synthesis has not been determined. Mice with an inducible knockout of ACSL1 (Acsl1T−/−) have impaired cardiac fatty acid oxidation and rely on glucose for ATP production. B...

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Bibliographic Details
Main Authors: Trisha J. Grevengoed, Sarah A. Martin, Lalage Katunga, Daniel E. Cooper, Ethan J. Anderson, Robert C. Murphy, Rosalind A. Coleman
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Journal of Lipid Research
Subjects:
heart fatty acid/metabolism
fatty acid/oxidation
phospholipids/biosynthesis
phospholipids/metabolism
cardiomyocyte dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355346

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http://www.sciencedirect.com/science/article/pii/S0022227520355346

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