PD-1-Mediated PI3K/Akt/mTOR, Caspase 9/Caspase 3 and ERK Pathways Are Involved in Regulating the Apoptosis and Proliferation of CD4+ and CD8+ T Cells During BVDV Infection in vitro

PD-1-Mediated PI3K/Akt/mTOR, Caspase 9/Caspase 3 and ERK Pathways Are Involved in Regulating the Apoptosis and Proliferation of CD4+ and CD8+ T Cells During BVDV Infection in vitro

Acute infection of bovine viral diarrhea virus (BVDV) is associated with immune dysfunction and can cause peripheral blood lymphopenia and lymphocyte apoptosis. Our previous study has confirmed that programmed death-1 (PD-1) blockade inhibits peripheral blood lymphocyte (PBL) apoptosis and restores...

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Bibliographic Details
Main Authors: Yu Liu, Shanshan Liu, Chenhua Wu, Wenjing Huang, Bin Xu, Shuai Lian, Li Wang, Shan Yue, Nannan Chen, Zhanbo Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
programmed death-1 (PD-1)
bovine viral diarrhea virus (BVDV)
immune dysfunction
PI3K/Akt/mTOR pathway
lymphocyte
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00467/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00467/full

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