Empagliflozin induces the transcriptional program for nutrient homeostasis in skeletal muscle in normal mice

Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve heart failure (HF) outcomes across a range of patient characteristics. A hypothesis that SGLT2i induce metabolic change similar to fasting has recently been proposed to explain their profound clinical benefits. However, it remains u...

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Bibliographic Details
Main Authors: Ryo Kawakami, Hiroki Matsui, Miki Matsui, Tatsuya Iso, Tomoyuki Yokoyama, Hideki Ishii, Masahiko Kurabayashi
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45390-y