PM2.5 triggers autophagic degradation of Caveolin-1 via endoplasmic reticulum stress (ERS) to enhance the TGF-β1/Smad3 axis promoting pulmonary fibrosis

PM2.5 triggers autophagic degradation of Caveolin-1 via endoplasmic reticulum stress (ERS) to enhance the TGF-β1/Smad3 axis promoting pulmonary fibrosis

Air pollution is highly associated with respiratory diseases. However, the influence and mechanism of particulate matter with aerodynamic equal to or less than 2.5 μm (PM2.5) in lung homeostasis remain unclear. Herein, we demonstrated the induction of pulmonary fibrosis (PF) by PM2.5 exposure. The a...

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Bibliographic Details
Main Authors: Huanliang Liu, Wenqing Lai, Huipeng Nie, Yue Shi, Lina Zhu, Linhui Yang, Lei Tian, Kang Li, Liping Bian, Zhuge Xi, Bencheng Lin
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Environment International
Subjects:
PM2.5
Caveolin-1
ERS
Autophagy
Pulmonary fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412023005639

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http://www.sciencedirect.com/science/article/pii/S0160412023005639

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