Organ-specific extracellular matrix directs trans-differentiation of mesenchymal stem cells and formation of salivary gland-like organoids in vivo

Organ-specific extracellular matrix directs trans-differentiation of mesenchymal stem cells and formation of salivary gland-like organoids in vivo

Abstract Background Current treatments for salivary gland (SG) hypofunction are palliative and do not address the underlying cause or progression of the disease. SG-derived stem cells have the potential to treat SG hypofunction, but their isolation is challenging, especially when the tissue has been...

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Bibliographic Details
Main Authors: Olivia N. Tran, Hanzhou Wang, Shengxian Li, Andrey Malakhov, Yuyang Sun, Parveez A. Abdul Azees, Aaron O. Gonzalez, Brian Cao, Milos Marinkovic, Brij B. Singh, David D. Dean, Chih-Ko Yeh, Xiao-Dong Chen
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Salivary gland
Regeneration
Mesenchymal stem cells
Stem cell niche
Cell trans-differentiation
Online Access:https://doi.org/10.1186/s13287-022-02993-y

Internet

https://doi.org/10.1186/s13287-022-02993-y

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