Synthetic NAC 71-82 Peptides Designed to Produce Fibrils with Different Protofilament Interface Contacts

Synthetic NAC 71-82 Peptides Designed to Produce Fibrils with Different Protofilament Interface Contacts

Alpha-synucleinopathies are featured by fibrillar inclusions in brain cells. Although α-synuclein fibrils display structural diversity, the origin of this diversity is not fully understood. We used molecular dynamics simulations to design synthetic peptides, based on the NAC 71-82 amino acid fragmen...

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Bibliographic Details
Main Authors: Thomas Näsström, Tobias Dahlberg, Dmitry Malyshev, Jörgen Ådén, Per Ola Andersson, Magnus Andersson, Björn C. G. Karlsson
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
NAC 71-82 peptides
fibril polymorphs
Online Access:https://www.mdpi.com/1422-0067/22/17/9334

Internet

https://www.mdpi.com/1422-0067/22/17/9334

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