Pharmacovigilance of Herb-Drug Interactions: A Pharmacokinetic Study on the Combined Administration of Tripterygium Glycosides Tablets and Leflunomide Tablets in Rats by LC-MS/MS

Pharmacovigilance of Herb-Drug Interactions: A Pharmacokinetic Study on the Combined Administration of Tripterygium Glycosides Tablets and Leflunomide Tablets in Rats by LC-MS/MS

A popular and widely used combination therapy of leflunomide (LEF) and Tripterygium glycosides tablets (TGT<sub>S</sub>) has become a valuable clinical tool in China for the treatment of rheumatoid arthritis. This regimen has not been evaluated either in terms of interaction or toxicity,...

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Bibliographic Details
Main Authors: Hamza Boucetta, Wei Wu, Tao Hong, Rui Cheng, Jing Jiang, Chengxi Liu, Min Song, Taijun Hang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
leflunomide
Tripterygium glycosides tablets
pharmacokinetics
herb–drug interactions
pharmacovigilance
LC-MS/MS
Online Access:https://www.mdpi.com/1424-8247/15/8/991

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https://www.mdpi.com/1424-8247/15/8/991

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