Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2

Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2

Abstract Bacterial sepsis results in high mortality rates, and new therapeutics to control infection are urgently needed. Here, we investigate the therapeutic potential of fibrates in the treatment of bacterial sepsis and examine their effects on innate immunity. Fibrates significantly improved the...

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Bibliographic Details
Main Authors: Ivan Tancevski, Manfred Nairz, Kristina Duwensee, Kristina Auer, Andrea Schroll, Christiane Heim, Clemens Feistritzer, Julia Hoefer, Romana R Gerner, Alexander R Moschen, Ingrid Heller, Petra Pallweber, Xiaorong Li, Markus Theurl, Egon Demetz, Anna M Wolf, Dominik Wolf, Philipp Eller, Andreas Ritsch, Guenter Weiss
Format: Article
Language:English
Published: Springer Nature 2014-06-01
Series:EMBO Molecular Medicine
Subjects:
chemokine receptor
fenofibrate
infection
inflammation
neutrophils
Online Access:https://doi.org/10.1002/emmm.201303415

Internet

https://doi.org/10.1002/emmm.201303415

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