Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5

Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5

The membrane attack complex (MAC or C5b-9) is an important effector of the immune system to kill invading microbes. MAC formation is initiated when complement enzymes on the bacterial surface convert complement component C5 into C5b. Although the MAC is a membrane-inserted complex, soluble forms of...

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Bibliographic Details
Main Authors: Dennis J Doorduijn, Marie V Lukassen, Marije FL van 't Wout, Vojtech Franc, Maartje Ruyken, Bart W Bardoel, Albert JR Heck, Suzan HM Rooijakkers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
complement
membrane attack complex
terminal complement complex
Escherichia coli
Staphylococcus
C5
Online Access:https://elifesciences.org/articles/77503

Internet

https://elifesciences.org/articles/77503

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