Peroxisomal defects in microglial cells induce a disease-associated microglial signature

Peroxisomal defects in microglial cells induce a disease-associated microglial signature

Microglial cells ensure essential roles in brain homeostasis. In pathological condition, microglia adopt a common signature, called disease-associated microglial (DAM) signature, characterized by the loss of homeostatic genes and the induction of disease-associated genes. In X-linked adrenoleukodyst...

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Bibliographic Details
Main Authors: Quentin Raas, Ali Tawbeh, Mounia Tahri-Joutey, Catherine Gondcaille, Céline Keime, Romain Kaiser, Doriane Trompier, Boubker Nasser, Valerio Leoni, Emma Bellanger, Maud Boussand, Yannick Hamon, Alexandre Benani, Francesca Di Cara, Caroline Truntzer, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
peroxisome
adrenoleukodystrophy (X-ALD)
microglia
lysosome
lipid metabolism
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1170313/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1170313/full

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