The Inhibition of Inwardly Rectifying K+ Channels by Memantine in Macrophages and Microglial Cells

The Inhibition of Inwardly Rectifying K+ Channels by Memantine in Macrophages and Microglial Cells

Background/Aims: Memantine (MEM) can block N-methyl-D-aspartate receptors non-competitively and is recognized to exert anti-inflammatory action. Whether MEM and other related compounds produce any effects on K+ currents in macrophages and in microglial cells is largely unknown. In this study, we inv...

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Bibliographic Details
Main Authors: Ke-Li Tsai, Hsueh-Fen Chang, Sheng-Nan Wu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Microglial cell
Channel kinetics
Membrane potential
Macrophage
Memantine
Inwardly rectifying potassium channel
Online Access:http://www.karger.com/Article/FullText/350112

Internet

http://www.karger.com/Article/FullText/350112

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