Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue.

We report the development of non-invasive, fiber-based diffuse optical spectroscopy for simultaneously quantifying vascular oxygenation (SO2) and glucose uptake in solid tumors in vivo. Glucose uptake was measured using a fluorescent glucose analog, 2-[N-(7-nitrobenz-2-oxa-1,3-diaxol-4-yl)amino]-2-d...

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Bibliographic Details
Main Authors: Narasimhan Rajaram, Andrew F Reesor, Christine S Mulvey, Amy E Frees, Nirmala Ramanujam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4311991?pdf=render