Characterization of AAV-mediated dorsal root ganglionopathy

Characterization of AAV-mediated dorsal root ganglionopathy

Recent studies in non-human primates administered recombinant adeno-associated viruses (rAAVs) have shown lesions in the dorsal root ganglia (DRG) of unknown pathogenesis. In this study, rAAV9s manufactured using different purification methods alongside a non-expressing Null AAV9 vector was administ...

Full description

Bibliographic Details
Main Authors: Nicholas Buss, Lisa Lanigan, Jillynne Zeller, Derek Cissell, Monica Metea, Eric Adams, Mikayla Higgins, Kwi Hye Kim, Ewa Budzynski, Lin Yang, Ye Liu, Mark Butt, Olivier Danos, Michele Fiscella
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
AAV9
DRG
toxicity
MRI
axonopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000146

Internet

http://www.sciencedirect.com/science/article/pii/S2329050122000146

Similar Items