Race-specific association of an IRGM risk allele with cytokine expression in human subjects

Race-specific association of an IRGM risk allele with cytokine expression in human subjects

Abstract Immunity-related GTPase family M (IRGM), located on human chromosome 5q33.1, encodes a protein that promotes autophagy and suppresses the innate immune response. The minor allele of rs13361189 (−4299T>C), a single nucleotide polymorphism in the IRGM promoter, has been associated with sev...

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Bibliographic Details
Main Authors: Teminioluwa Ajayi, Prashant Rai, Min Shi, Kristin A. Gabor, Peer W. F. Karmaus, Julie M. Meacham, Kevin Katen, Jennifer H. Madenspacher, Shepherd H. Schurman, Michael B. Fessler
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40313-3

Internet

https://doi.org/10.1038/s41598-023-40313-3

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