Treprostinil inhibits functional activation of scleroderma (SSc) vascular smooth muscle cells (vSMCs) by inhibiting Yap and activating PPARG signaling.
Background: Progressive vascular wall thickness and fibrosis are the hallmarks of SSc vasculopathy. Overexpression of TGFB1 in SSc and activation of vSMCs are important steps in the pathogenesis of SSc vascular disease. Objectives: In this study, we examined the expression levels of COL1,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
The University of Toledo
2023-12-01
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| Series: | Translation |
| Subjects: | |
| Online Access: | https://openjournals.utoledo.edu/index.php/translation/article/view/908 |