Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production

Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production

Abstract Dihydroartemisinin (DHA), a natural product derived from the herbal medicine Artemisia annua, is recently used as a novel anti-cancer agent. However, some intrinsic disadvantages limit its potential for clinical management of cancer patients, such as poor water solubility and low bioavailab...

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Bibliographic Details
Main Authors: Yuanliang Yan, Xiaoxin Yang, Ning Han, Yuanhong Liu, Qiuju Liang, Liu-Gen Li, Jun Hu, Tong-Fei Li, Zhijie Xu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Nanobiotechnology
Subjects:
Dihydroartemisinin
Metal-organic framework
ROS production
Cell apoptosis
Ovarian cancer
Online Access:https://doi.org/10.1186/s12951-023-01959-3

Internet

https://doi.org/10.1186/s12951-023-01959-3

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