Histidine Protonation and Conformational Switching in Diphtheria Toxin Translocation Domain

Histidine Protonation and Conformational Switching in Diphtheria Toxin Translocation Domain

Protonation of key histidine residues has been long implicated in the acid-mediated cellular action of the diphtheria toxin translocation (T-) domain, responsible for the delivery of the catalytic domain into the cell. Here, we use a combination of computational (constant-pH Molecular Dynamics simul...

Full description

Bibliographic Details
Main Authors: Mykola V. Rodnin, Victor Vasques-Montes, Alexander Kyrychenko, Nuno F. B. Oliveira, Maithri M. Kashipathy, Kevin P. Battaile, Justin Douglas, Scott Lovell, Miguel Machuqueiro, Alexey S. Ladokhin
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Toxins
Subjects:
diphtheria toxin structure
NMR spectroscopy
mutations of histidines
X-ray crystallography
constant-pH simulations
acidification
Online Access:https://www.mdpi.com/2072-6651/15/7/410

Internet

https://www.mdpi.com/2072-6651/15/7/410

Similar Items