Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells

Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells

Abstract Estrogen receptor alpha (ERα) is a ligand-dependent master transcriptional regulator and key driver of breast cancer pathology. Small molecule hormones and competitive antagonists favor unique ERα conformational ensembles that elicit ligand-specific transcriptional programs in breast cancer...

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Bibliographic Details
Main Authors: G. R. Hancock, K. S. Young, D. J. Hosfield, C. Joiner, E. A. Sullivan, Y. Yildiz, M. Lainé, G. L. Greene, S. W. Fanning
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00497-9

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https://doi.org/10.1038/s41523-022-00497-9

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