Anti‐N‐homocysteine‐protein autoantibodies are associated with impaired cognition

Anti‐N‐homocysteine‐protein autoantibodies are associated with impaired cognition

Abstract Introduction Elevated homocysteine (Hcy) and related metabolites accelerate Alzheimer's disease. Hcy‐lowering B vitamins slow brain atrophy/cognitive decline in mild cognitive impairment (MCI). Modification with Hcy‐thiolactone generates auto‐immunogenic N‐Hcy‐protein. We tested a hypo...

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Bibliographic Details
Main Authors: Olga Włoczkowska, Joanna Perła‐Kaján, A. David Smith, Celeste deJager, Helga Refsum, Hieronim Jakubowski
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
anti‐N‐Hcy‐protein autoantibodies
brain atrophy
cognition
homocysteine
mild cognitive impairment
Online Access:https://doi.org/10.1002/trc2.12159

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