Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.

Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.

Pathologic conditions impair bone homeostasis. The transcription factor NF-κB regulates bone homeostasis and is central to bone pathologies. Whereas contribution of NF-κB to heightened osteoclast activity is well-documented, the mechanisms underlying NF-κB impact on chondrocytes and osteoblasts are...

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Bibliographic Details
Main Authors: Gaurav Swarnkar, Kaihua Zhang, Gabriel Mbalaviele, Fanxin Long, Yousef Abu-Amer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3949987?pdf=render

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http://europepmc.org/articles/PMC3949987?pdf=render

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