Structure-Based Virtual Screening of <i>Pseudomonas aeruginosa</i> LpxA Inhibitors using Pharmacophore-Based Approach

Structure-Based Virtual Screening of <i>Pseudomonas aeruginosa</i> LpxA Inhibitors using Pharmacophore-Based Approach

Multidrug resistance in <i>Pseudomonas aeruginosa</i> is a noticeable and ongoing major obstacle for inhibitor design. In <i>P. aeruginosa,</i> uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) acetyltransferase (PaLpxA) is an essential enzyme of lipid A biosynthesis and a...

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Bibliographic Details
Main Authors: Baki Vijaya Bhaskar, Tirumalasetty Muni Chandra Babu, Aluru Rammohan, Gui Yu Zheng, Grigory V. Zyryanov, Wei Gu
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
palpxa
docking
pharmacophore
virtual screening
gbvi
adme
Online Access:https://www.mdpi.com/2218-273X/10/2/266

Internet

https://www.mdpi.com/2218-273X/10/2/266

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