Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein

Heterotrimeric G-proteins are signal transducers involved in mediating the action of many natural extracellular stimuli and many therapeutic agents. Non-invasive approaches to manipulate the activity of G-proteins with high precision are crucial to understand their regulation in space and time. Here...

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Bibliographic Details
Main Authors: Mikel Garcia-Marcos, Kshitij Parag-Sharma, Arthur Marivin, Marcin Maziarz, Alex Luebbers, Lien T Nguyen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/60155